Table 5.
Calculation | Penetration ratio | AUC0-24 |
|
---|---|---|---|
Free plasmaa | ELF | ||
Mean | 39.7 | 2.67 | 106.0 |
Median | 36.3 | 2.59 | 93.9 |
SD | 82.3 | 0.68 | 55.9 |
Percentile of the distribution | |||
5th | 23.9 | 1.71 | 40.9 |
10th | 26.3 | 1.87 | 49.3 |
25th | 30.6 | 2.19 | 66.9 |
50th | 36.3 | 2.59 | 93.9 |
75th | 42.8 | 3.07 | 131.4 |
90th | 49.7 | 3.57 | 177.7 |
95th | 54.6 | 3.90 | 213.0 |
The plasma AUC is corrected for mean protein binding (89.44%).