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. 2012 May;56(5):2627–2634. doi: 10.1128/AAC.05354-11

Table 5.

ELF penetration and AUC0-24 values in plasma and ELF after 9,999-subject Monte Carlo simulation

Calculation Penetration ratio AUC0-24
Free plasmaa ELF
Mean 39.7 2.67 106.0
Median 36.3 2.59 93.9
SD 82.3 0.68 55.9
Percentile of the distribution
    5th 23.9 1.71 40.9
    10th 26.3 1.87 49.3
    25th 30.6 2.19 66.9
    50th 36.3 2.59 93.9
    75th 42.8 3.07 131.4
    90th 49.7 3.57 177.7
    95th 54.6 3.90 213.0
a

The plasma AUC is corrected for mean protein binding (89.44%).