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PK studies. Serum concentrations (conc.) of colistin (A) and imipenem (B) in mice after intraperitoneal treatment with doses from 8 mg/kg to 256 mg/kg are shown. The y axis in both panels is log10. The MICs against P. aeruginosa PAO1 were 4 mg/liter for colistin and 1 mg/liter for imipenem.
