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Growth curves of control and antibiotic-exposed planktonic and biofilm P. aeruginosa PAO1 cells in the neutropenic mouse lung after a single intraperitoneal dose of colistin and imipenem. MIC of colistin, 4 μg/ml; MIC of imipenem, 1 μg/ml. Color bars denote the interval that serum levels of antibiotic concentrations exceeded the MIC (TMIC). (A) Colistin versus planktonic bacteria; (B) colistin versus biofilms; (C) imipenem versus planktonic bacteria; (D) imipenem versus biofilms.
