Table 1.
Values of pharmacokinetic parameters for colistin and imipenem following intraperitoneal administration of a single dose in mice with biofilm bacterial lung infectiona
| Drug and dose (mg/kg) | Cmax (mg/liter) | Tmax (min) | AUCtot (mg · min/liter) | Vz/F (ml/kg) | Vss/F (ml/kg) | CL/F (ml/min/kg) | t1/2 (min) | MRT (min) |
|---|---|---|---|---|---|---|---|---|
| Colistin | ||||||||
| 16 | 21 (3.1) | 25 (7.8) | 1,119 (240) | 676 (300) | 868 (314) | 15 (3.3) | 31 (6.6) | 58 (10) |
| 64 | 83 (5.6) | 28 (6.1) | 5,766 (542) | 875 (108) | 761 (84) | 11 (1) | 54 (2.6) | 68 (2.3) |
| 256 | 264 (31) | 35 (12) | 24,527 (2,679) | 803 (189) | 871 (84) | 11 (1.1) | 53 (13) | 83 (7.7) |
| Imipenem | ||||||||
| 8 | 15 (7.1) | 21 (11) | 1,470 (777) | 648 (330) | 721 (343) | 6.7 (3) | 67 (11) | 108 (12) |
| 16 | 34 (6) | 28 (18) | 2,857 (559) | 507 (140) | 543 (121) | 5.8 (1) | 60 (9.1) | 94 (10) |
| 32 | 54 (11) | 18 (6.1) | 4,895 (635) | 516 (75) | 566 (83) | 6.6 (0.8) | 54 (6.5) | 86 (11) |
| 64 | 69 (37) | 15 (9.5) | 6,037 (2,976) | 547 (274) | 617 (308) | 7.4 (3.6) | 43 (22) | 70 (35) |
a
The doses are 16 to 256 mg/kg of colistin and 8 to 64 mg/kg of imipenem. Data in parentheses are the standard deviation (SD).