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PAEs of colistin and imipenem after single-dose therapy against P. aeruginosa PAO1 in the lung infection model of neutropenic mice
| Drug and dose (mg/kg) | TMIC (h) | TMBIC (h) | PAE (h)a |
||
|---|---|---|---|---|---|
| Planktonic cells (TMIC) | Biofilm cells |
||||
| TMIC | TMBIC | ||||
| Colistin | |||||
| 16 | 1.6 | 0.9 | 0.9 | −0.9 | −0.1 |
| 64 | 3 | 2 | 1 | −1.5 | −1.2 |
| 256 | 5 | 4 | 1.5 | −2.1 | −2 |
| Imipenem | |||||
| 4 | 5 | 0 | −2.8 | −3 | |
| 16 | 5.7 | 2 | 6.8 | −2.7 | −1.5 |
| 64 | 5.9 | 3 | 12 | −2.4 | −1.2 |
The indicated parameters (TMIC and TMBIC) were involved in the PAE calculation.
