Table 2.
Drug and dose (mg/kg) | TMIC (h) | TMBIC (h) | PAE (h)a |
||
---|---|---|---|---|---|
Planktonic cells (TMIC) | Biofilm cells |
||||
TMIC | TMBIC | ||||
Colistin | |||||
16 | 1.6 | 0.9 | 0.9 | −0.9 | −0.1 |
64 | 3 | 2 | 1 | −1.5 | −1.2 |
256 | 5 | 4 | 1.5 | −2.1 | −2 |
Imipenem | |||||
4 | 5 | 0 | −2.8 | −3 | |
16 | 5.7 | 2 | 6.8 | −2.7 | −1.5 |
64 | 5.9 | 3 | 12 | −2.4 | −1.2 |
The indicated parameters (TMIC and TMBIC) were involved in the PAE calculation.