Table 3.
PK/PD model parameter estimates for prediction of viable counts for AUC/MIC, MBIC index for colistin, and TMIC and TMBIC for imipenem against P. aeruginosa PAO1 in the lung infection model of neutropenic mice
| Antibiotic and cell type (parameter) | Emax (log10 no. of CFU/lung) | E0 (log10 no. of CFU/lung) | EC50 | γ |
|---|---|---|---|---|
| Colistina | ||||
| Planktonic (AUC/MIC) | −4.4 (28)b | 6.2 (2.8) | 3,840 (17) | 4.1 (57) |
| Biofilm (AUC/MIC) | −2.2 (61) | 8.3 (1.7) | >18,420 | 1.7 (60) |
| Biofilm (AUC/MBIC) | −2.2 (61) | 8.3 (1.7) | >9,180 | 1.7 (42) |
| Imipenemc | ||||
| Planktonic (TMIC) | −6.6 (0.3) | 8.6 (0.1) | 3.4 (0.3) | 2 (0.5) |
| Biofilm (TMIC) | −6.6 (0.3) | 9 (0.1) | 4.6 (0.2) | 1.2 (0.9) |
| Biofilm (TMBIC) | −6.8 (0.2) | 9 (0.1) | 2.4 (0.1) | 2 (0.2) |
a
AUC, mg · min/liter.
b
Data in parentheses are percent relative standard error.
c
In hours.