Table 3.
Antibiotic and cell type (parameter) | Emax (log10 no. of CFU/lung) | E0 (log10 no. of CFU/lung) | EC50 | γ |
---|---|---|---|---|
Colistina | ||||
Planktonic (AUC/MIC) | −4.4 (28)b | 6.2 (2.8) | 3,840 (17) | 4.1 (57) |
Biofilm (AUC/MIC) | −2.2 (61) | 8.3 (1.7) | >18,420 | 1.7 (60) |
Biofilm (AUC/MBIC) | −2.2 (61) | 8.3 (1.7) | >9,180 | 1.7 (42) |
Imipenemc | ||||
Planktonic (TMIC) | −6.6 (0.3) | 8.6 (0.1) | 3.4 (0.3) | 2 (0.5) |
Biofilm (TMIC) | −6.6 (0.3) | 9 (0.1) | 4.6 (0.2) | 1.2 (0.9) |
Biofilm (TMBIC) | −6.8 (0.2) | 9 (0.1) | 2.4 (0.1) | 2 (0.2) |
AUC, mg · min/liter.
Data in parentheses are percent relative standard error.
In hours.