Table 4.

Target values of colistin (AUC/MIC, MBIC) and imipenem (T_MIC, T_MBIC) for stasis and 1- and 2-log₁₀-unit kill against P. aeruginosa PAO1 in the lung infection model of neutropenic mice

Kill effect	Target value of antibiotics
	Colistina			Imipenemb
	Planktonic (AUC/MIC)	Biofilms		Planktonic (TMIC)	Biofilms
		AUC/MIC	AUC/MBIC		TMIC	TMBIC
Static	10,020	30,000	3,780	5.5	7.5	3.2
1 log10	17,820	52,020	11,100	7.5	11	5.2
2 log10	25,980	61,980	13,080	10	18	8

^aAUC, mg · min/liter.

^bIn hours.