Table 5.

Values of pharmacokinetics and pharmacodynamics modeling in P. aeruginosa biofilm infection model of leucopenia mice

Drug and dose (mg/kg)	Cmax/MIC	Cmax/MBC	Cmax/MBIC	Cmax/MBEC	AUC/MICa	AUC/MBC	AUC/MBIC	AUC/MBEC	TMBC (h)b	TMBEC (h)
Colistin
16	5.4	2.7	2.7	0.3	280	140	140	18	0.9	0
64	21	10	10	1.3	1,442	721	721	90	2	0.7
256	66	33	33	4.1	6,132	3,066	3,066	383	4	2.3
Imipenem
8	15	3.9	1.9	0.12	1,470	368	184	11	1.8	0
16	34	8.5	4.3	0.27	2,857	714	357	22	3	0
32	54	14	6.8	0.43	4,895	1,224	612	38	3.8	0
64	69	17	8.6	0.54	6,037	1,509	755	47	4.2	0

^aAUC, mg · min/liter.

^bT_MIC and T_MBIC in Table 2.