Table 5.
Drug and dose (mg/kg) | Cmax/MIC | Cmax/MBC | Cmax/MBIC | Cmax/MBEC | AUC/MICa | AUC/MBC | AUC/MBIC | AUC/MBEC | TMBC (h)b | TMBEC (h) |
---|---|---|---|---|---|---|---|---|---|---|
Colistin | ||||||||||
16 | 5.4 | 2.7 | 2.7 | 0.3 | 280 | 140 | 140 | 18 | 0.9 | 0 |
64 | 21 | 10 | 10 | 1.3 | 1,442 | 721 | 721 | 90 | 2 | 0.7 |
256 | 66 | 33 | 33 | 4.1 | 6,132 | 3,066 | 3,066 | 383 | 4 | 2.3 |
Imipenem | ||||||||||
8 | 15 | 3.9 | 1.9 | 0.12 | 1,470 | 368 | 184 | 11 | 1.8 | 0 |
16 | 34 | 8.5 | 4.3 | 0.27 | 2,857 | 714 | 357 | 22 | 3 | 0 |
32 | 54 | 14 | 6.8 | 0.43 | 4,895 | 1,224 | 612 | 38 | 3.8 | 0 |
64 | 69 | 17 | 8.6 | 0.54 | 6,037 | 1,509 | 755 | 47 | 4.2 | 0 |
AUC, mg · min/liter.
TMIC and TMBIC in Table 2.