Table 3.
Antibiotic susceptibility of A. baumannii strains
| Antimicrobial agent | MICa (μg/ml) for strain: |
||||
|---|---|---|---|---|---|
| BM4587b | BM4666 (BM4587 adeNΔC582)c | BM4666/pAT522 (adeN)d | BM4685 (BM4587 ΔadeN)e | BM4685/pAT522 (adeN)d | |
| Erythromycin | 6 | 32 | 6 | 24 | 4 |
| Chloramphenicol | 64 | >256 | 32 | 128 | 24 |
| Tetracycline | 3 | 8 | 1.5 | 4 | 0.75 |
| Minocycline | 0.094 | 0.38 | 0.094 | 0.38 | 0.094 |
| Tigecycline | 0.064 | 0.25 | 0.094 | 0.25 | 0.064 |
| Rifampin | 1.5 | 3 | 3 | 8 | 4 |
| Ciprofloxacin | 0.125 | 0.38 | 0.25 | 0.5 | 0.125 |
| Norfloxacin | 1.5 | 6 | 3 | 6 | 3 |
| Trimethoprim | 24 | >32 | 16 | >32 | 24–32 |
| Sulfamethoxazole | 4 | 8 | 3 | 16 | 6 |
| Co-trimoxazole | 0.19 | 0.38 | 0.125 | 0.75 | 0.25 |
| Ticarcillin | 8 | 16 | NAf | 64 | NA |
| Aztreonam | 12 | 48 | 16 | 32 | 12 |
| Cefepime | 1 | 3 | 2 | 3 | 1.5 |
| Ceftazidime | 2 | 6 | 2 | 3 | 1.5 |
| Imipenem | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 |
| Ertapenem | 3 | 12 | 3 | 6 | 1.5 |
| Meropenem | 0.25 | 1 | 0.38 | 0.75 | 0.19 |
a
MICs determined by Etest.
b
Wild-type clinical isolate.
c
Mutant of BM4587 overexpressing adeIJK.
d
Strain trans-complemented with plasmid pAT522 (adeN).
e
Derivative of BM4587 deleted for adeN and overexpressing adeIJK.
f
NA, not assessed because of the presence of an ampicillin resistance cassette.