Table 2.
Genetic alterations of ureaplasmas with elevated levofloxacin MICs
| Species and isolate | MIC (μg/ml)a |
Genetic alteration(s)b |
|||||
|---|---|---|---|---|---|---|---|
| Levo | Ery | Tet | gyrA | gyrB | parC | parE | |
| U. urealyticum | |||||||
| 25353 | 8 | ≥256 | 16 | A2399T (N800I) | T355C (L119S) | C248T (S83L), C1265A (A422E), A1646G (H549R) | G866A (S289N) |
| U. parvum | |||||||
| 26554 Up | 8 | 1 | 0.25 | G259A (E87K) | |||
| 48105 Up | 32 | 2 | 0.5 | C310A (Q104K) | C248T (S83L) | G1369A (A457T) | |
| 48736 Up | 4 | 1 | 0.5 | C1409T (S470L) | |||
| 48874 Up | 8 | 2 | 0.5 | C248T (S83L) | |||
| 49063 Up | 16 | 2 | 2 | C248T (S83L) | |||
| 50056 Up | 8 | 2 | 0.063 | C248T (S83L) | |||
| 50186 Up | 4 | 1 | 32 | C5T (A2V), A1280T (D427V) | |||
| 50892 Up | 4 | 1 | 2 | C248T (S83L) | |||
| 51110 Up | 8 | 2 | 0.5 | C1384T (P462S) | C248T (S83L), A2556 deletion | ||
| 53051 Up | 4 | 1 | 16 | C248T (S83L), G1342A (D448N), C1344T (D448N), G1588A (D530N), C1657A (L553I), A1708G (T570A), A2104G (I702V), G2203A (A735S), C2204G (A735S), A2229G (I743 M), C2370G (I790 M), G2380A (D794N), G2395A (D799N), | |||
| 55576 Up | 8 | 0.5 | 0.25 | T8A (V3E) | |||
| C248T (S83L) | |||||||
| 56082 Up | 4 | 2 | 1 | C248T (S83L) | |||
a
Abbreviations: Levo, levofloxacin; Ery, erythromycin; Tet, tetracycline.
b
Parentheses indicate amino acid substitutions that occurred as a result of DNA point mutations. Boldface indicates polymorphisms found in levofloxacin-susceptible clinical isolates but not in the 14 ATCC type strains.