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Time-kill curves of fluconazole and amphotericin B alone or in combination against 14 C. gattii strains. (A) Time-kill curve performed with fluconazole at 1× MIC (●), 2× the MIC (■), and 4× the MIC (▲). (B) Time-kill curve performed with amphotericin B (MIC). (C) Time-kill curve performed with antifungal combinations: FLC (1.0 μg/ml) + AMB (MIC) (♦), FLC (4.0 μg/ml) + AMB (MIC) (■), and FLC (16.0 μg/ml) + AMB (MIC) (▲). AMB, amphotericin B; FLC, fluconazole.
