Table 5.
Polymorphism of Pfcrt, PfATPase6, Pfdhfr and Pfdhps genes in study population
| Candidate genea | Occurrence of mutation |
||
|---|---|---|---|
| n | % | 95% CI | |
| Pfcrt (n = 139) | |||
| Haplotypes | |||
| S72V73M74N75T76 | 120 | 86.3 | 80.62–92.04 |
| C72V73I74E75T76 | 19 | 13.7 | 7.96–19.38 |
| PfATPase6 (n = 142) | |||
| Synonymous mutation | |||
| G468G | 4 | 2.8 | 0.1–5.54 |
| N483N | 7 | 4.9 | 1.37–8.49 |
| I898I | 38 | 26.8 | 17.56–31.74 |
| Nonsynonymous mutation | |||
| E431K | 27 | 19.0 | 12.56–25.46 |
| K649E | 36 | 25.4 | 18.19–32.51 |
| N683K | 8 | 5.6 | 1.84–9.42 |
| Pfdhfr (n = 138) | |||
| A16V | 0 | 0 | 0–2.13 |
| N51I | 13 | 9.4 | 4.55–14.29 |
| C59R | 138 | 100.0 | 97.87–100.69 |
| S108N | 132 | 95.7 | 92.25–99.05 |
| I164L | 8 | 5.8 | 1.9–9.7 |
| Genotype | |||
| A16I51R59S108I164 | 6 | 4.3 | 0.95–7.75 |
| A16N51R59N108I164 | 117 | 84.8 | 78.79–90.77 |
| A16N51R59N108L164 | 8 | 5.8 | 1.9–9.7 |
| A16I51R59N108I164 | 7 | 5.1 | 1.41–8.73 |
| Pfdhps (n = 126) | |||
| S436A | 63 | 50.0 | 41.27–58.73 |
| A437G | 42 | 33.3 | 25.1–41.56 |
| K540E | 64 | 50.8 | 42.06–59.52 |
| A581G | 7 | 5.6 | 1.56–9.56 |
| A613S | 0 | 0 | 0–2.34 |
| Genotype | |||
| S436A437K540A581A613 | 6 | 4.8 | 1.04–8.48 |
| A436A437K540A581A613 | 7 | 5.6 | 1.56–9.56 |
| S436G437K540A581A613 | 42 | 33.3 | 25.1–41.56 |
| S436A437E540A581A613 | 8 | 6.3 | 2.09–10.61 |
| S436A437K540G581A613 | 7 | 5.6 | 1.56–9.56 |
| A436A437E540A581A613 | 56 | 44.4 | 35.76–53.12 |
a
Mutated amino acids are in boldface.