Table 1.
MICs of itraconazole, voriconazole, and posaconazole for 296 A. fumigatus clinical isolatesa
| Parameter | No. of isolates (no. with cyp51A mutations), value, or status for: |
||
|---|---|---|---|
| Itraconazole | Voriconazole | Posaconazole | |
| MICs (mg/liter) | |||
| ≤0.03 | 1 (0) | 0 | 37 (2) |
| 0.06 | 2 (0) | 0 | 36 (4) |
| 0.13 | 43 (1) | 0 | 15 (3) |
| 0.25 | 34 (3) | 27 (4) | 59 (49) |
| 0.5 | 9 (2) | 44 (3) | 111 (102) |
| 1 | 3 (1) | 30 (9) | 28 (25) |
| 2 | 0 | 41 (32) | 3 (2) |
| 4 | 2 (2) | 68 (61) | 0 |
| 8 | 6 (4) | 54 (52) | 0 |
| 16 | 19 (16) | 28 (28) | 0 |
| 32 | 176 (162) | 4 (3) | 7 (6) |
| ≥64 | 1 (1) | 0 | 0 |
| Characteristics of MIC data | |||
| Median | 32.0 | 4.0 | 0.5 |
| Mode | 32.0 | 4.0 | 0.5 |
| Minimum | 0.03 | 0.25 | 0.02 |
| Maximum | 128.0 | 32.0 | 32.0 |
| Skewness | −0.8339 | −0.2133 | 0.3632 |
| Kurtosis | −1.177 | −0.9978 | 2.121 |
| D'Agostino-Pearson omnibus normality test results | |||
| K2 | 166.0 | 57.23 | 24.10 |
| P value | <0.0001 | <0.0001 | <0.0001 |
| Passed | No | No | No |
a
Numbers in parentheses represent isolates with Cyp51 mutations. Descriptive characteristics (median, range, skewness, and kurtosis) of the MIC distributions for three azoles after log transformation, together with the results of the D'Agostino-Pearson normality test, are presented.