Table 2.
Determinants of Cmax in fast and slow absorbers of rifampina
| Determinant | Geometric mean Cmax (mg/liter) for fast absorbers (2 h) (n = 37) | P value for fast absorbers | Geometric mean Cmax (mg/liter) for slow absorbers (6 h) (n = 61) | P value for slow absorbers |
|---|---|---|---|---|
| TB comorbidity | ||||
| DM-TB | 5.1 | 0.99 | 3.4 | 0.29 |
| HIV-TB | 4.8 | 0.76 | 3.1 | 0.10 |
| None | 5.1 | 4.5 | ||
| Sex | ||||
| Male | 4.4 | 0.009 | 2.7 | <0.001 |
| Female | 6.7 | 6.1 | ||
| Phase of treatment | ||||
| Intensive phase | 5.5 | 0.64 | 3.4 | 0.06 |
| Maintenance phase | 4.9 | 4.7 | ||
| Age group | ||||
| 18–30 yr | 5.0 | 0.93 | 4.4 | 0.61 |
| 31–40 yr | 4.9 | 3.5 | ||
| >40 yrs | 5.2 | 3.5 | ||
| Presence of intestinal parasites | ||||
| Yes | 3.9 | 0.40 | 3.0 | 0.49 |
| No | 5.1 | 3.8 | ||
| Overall geometric mean | 5.0 | 3.8 |
a
Numerical values are expressed as geometric means. Comparisons of groups were made between DM-TB or HIV-TB group and the TB (non-HIV, non-DM) group. All the variables were analyzed by using the independent-sample t test on the natural logarithm-transformed data.