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Antimycobacterial activity of JVA, a highly hydrophobic isoniazid analogue. (A) Preparation of JVA. (B) Partition coefficient (log P) (dichloromethane/water) of INH and JVA as described in Materials and Methods. (C) M. tuberculosis H37Rv cultures were exposed to different concentrations of INH or JVA for 7 days, and bacterial viability was determined by CFU counts or MTT-based assay (right) as described in Materials and Methods.
