Table 2.
Pharmacokinetic parameters for single-day (day 1) and repeat (day 7) dosing of GSK2248761
| Plasma GSK2248761 PK parametera | Value for GSK2248761 dose (mg) ofb: |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 30 |
100 |
200 |
400 |
800 |
||||||
| Day 1 | Day 7 | Day 1 | Day 7 | Day 1 | Day 7 | Day 1 | Day 7 | Day 1 | Day 7 | |
| AUC (ng · h/ml) | 2,404 (1,108) | 3,244 (1,738) | 10,102 (2,128) | 12,276 (3,808) | 26,504 (12,396) | 30,427 (14,442) | 37,757 (22,013) | 51,139 (13,577) | 47,863 (38,947) | 66,123 (47,837) |
| Cmax (ng/ml) | 186 (70) | 228 (94) | 831 (268) | 984 (223) | 1,735 (428) | 2,281 (820) | 2,746 (939) | 4,223 (909) | 3,539 (1,108) | 5,905 (2,738) |
| Cτ (ng/ml) | 36 (20) | 66 (50) | 138 (52) | 229 (111) | 400 (244) | 602 (380) | 528 (429) | 962 (456) | 672 (832) | 1,016 (1,267) |
| Tmax (h) | 4 (3–6) | 4 (3–6) | 4 (3–6) | 5 (3–6) | 4 (3–6) | 5 (4–6) | 3 (3–6) | 4 (3–6) | 4.5 (3–8) | 5 (2–8) |
a
AUC represents AUC0-∞ for day 1 and AUC0-τ for day 7. Tmax, time to the maximum observed concentration.
b
Values are reported as mean (standard deviation), except for Tmax where medians (ranges) are reported.