Table 4.
Respiratory tract culture results, stratified by voriconazole troughs at the time of culture
| Voriconazole trough | % of positive cultures (n = 53)a |
% of total positive cultures (n = 53)a | % of negative cultures (n = 104)a | P valued | |
|---|---|---|---|---|---|
| IFIb (n = 10) | Colonizationc (n = 43) | ||||
| ≤0.5 μg/ml | 10 (1/10) | 23 (10/43) | 21 (11/53) | 22 (23/104) | 1.0 |
| >0.5 μg/ml | 90 (9/10) | 77 (33/43) | 79 (42/53) | 78 (81/104) | |
| ≤1 μg/ml | 50 (5/10) | 51 (22/43) | 51 (27/53) | 35 (36/104) | 0.06 |
| >1 μg/ml | 50 (5/10) | 49 (21/43) | 49 (26/53) | 65 (68/104) | |
| ≤1.5 μg/ml | 60 (6/10) | 70 (30/43) | 68 (36/53) | 46 (48/104) | 0.01 |
| >1.5 μg/ml | 40 (4/10) | 30 (13/43) | 32 (17/53) | 54 (56/104) | |
| ≤2 μg/ml | 70 (7/10) | 72 (31/43) | 72 (38/53) | 58 (60/104) | NS (0.12) |
| >2 μg/ml | 30 (3/10) | 28 (12/43) | 28 (15/53) | 42 (44/104) | |
The values in parentheses are the number of positive or negative cultures to the total number of cultures.
Anastomotic tracheobronchits was caused by Candida glabrata (n = 3), Candida albicans (n = 2), a yeast species that was not identified to the species level (n = 1), Penicillium (n = 1), Aspergillus niger (n = 1), and an unidentified mold (n = 2).
Colonization was caused by 19 Candida isolates (9 C. glabrata isolates, 6 C. albicans isolates, 2 C. krusei isolates, and one isolate each of C. tropicalis and C. parapsilosis, and 24 mold isolates (9 Penicillium isolates, 6 Aspergillus niger isolates, 2 Fusarium isolates, 2 Rhizopus isolates, 1 Scedosporium isolate, 1 Lecythofora isolate, and 3 unidentified molds). Seven patients were colonized for a single episode, and 18 patients were colonized for two episodes at unique times.
The P values result from a comparison of values for the 53 positive cultures compared to the values for the 104 negative cultures at their respective troughs. NS, not significant.