Table 4.
Median MICs
| Straina | MIC (μg/ml) of ceftriaxoneb |
|---|---|
| WT (vector) | 8 |
| ΔireK (vector) | 2 |
| ΔireK (P-murAA) | 16 |
| ΔireK (P-murAA C120S) | 4 |
| ΔireK (P-EcmurA) | 4 |
| croR::Tn (vector) | 4 |
| croR::Tn (P-murAA) | 4 |
| Δpbp5 (vector) | 1 |
| Δpbp5 (P-murAA) | 1 |
a
Strains were WT (OG1RF), ΔireK mutant (CK119), croR::Tn strain (CK128), and Δpbp5 mutant (JL104). Plasmids were vector, pDL278p23, P-murAA C120S (pDV15-1), P-EcmurA (pJMK4), and P-murAA (pDV27-4).
b
MIC determined in MHB supplemented with Sp (100 μg/ml) after 24 h of incubation at 37°C from a minimum of three independent experiments.