Figure 5.
Anti-tumor activity in NCI-H929 s.c. xenograft model. (a) NCI-H929 cells (1 × 107 cells/mouse) were inoculated s.c. into the flank of severe combined immunodeficient mice. After 10 days, KW-2478 (KW) or/and bortezomib (BTZ) were administered i.v. twice weekly for 2 weeks. Each plot represents the mean+s.d. of tumor volume (n=5). *P<0.05; Steel–Dwass test. (b) Fourteen days after the initial administration, serum M protein concentrations were measured. Each bar represents the mean+s.d. (n=5), *P<0.05; Tukey's test.