Figure 6.
Anti-tumor activity in OPM-2/GFP orthotopic model. OPM-2/GFP cells (1 × 107 cells/mouse) were inoculated i.v. into severe combined immunodeficient (SCID) mice. (a) Thirty-three days after cell inoculation, GFP fluorescence was measured followed by histochmical examination, (b) Twenty-seven days after cell inoculation, KW-2478 (KW) or/and bortezomib (BTZ) were administered i.v. twice weekly for 2 weeks. Photographs were taken 50 days after cell inoculation from dorsal angle. (c) Forty days after cell inoculation, serum M protein concentration was measured by ELISA. Each column represents the mean+s.d. n=5. *P<0.05; Tukey's test.