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| Treatment | Day 0 | Day 4 | Day 7 | Day 10 | Day 14 | Day 17 | Day 21 |
|---|---|---|---|---|---|---|---|
| No treat (control) | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 |
| BTZ 1 mg/kg biw × 2 | 1.000 | 0.775 | 0.620 | 0.594 | 0.445 | 0.478 | 0.490 |
| KW-2478 50 mg/kg biw × 2 | 1.000 | 0.544 | 0.522 | 0.423 | 0.305 | 0.304 | 0.353 |
| KW (50, biw × 2) + BTZ | 1.000 | 0.274 | 0.234 | 0.153 | 0.084 | 0.096 | 0.117 |
| KW (50, biw × 2) + BTZ (calculated) | 1.000 | 0.422 | 0.323 | 0.251 | 0.136 | 0.146 | 0.173 |
Abbreviations: BTZ, bortezomib; KW, KW-2478.
