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| Cardinal symptoms | Number of mast cells/HPF | Serum markers | |
|---|---|---|---|
| Mastocytic enterocolitis | Abdominal pain, diarrhea | >20 | N/A |
| Mast cell Activation syndrome | Abdominal pain, dermatographism, flushing | 17–23 | Serum tryptase |
| Allergic mastocytic Gastroenteritis and colitis | Abdominal pain, dysmotilitysymptoms (e.g., early satiety, bloating), nocturnal awakening | >40 | Histamine, IgE |
