Fig. 3.

Effects of coupling between INS and extra-cluster DVR on INS fluid composition and water absorption from CD. Shown are INS fluid osmolality (top), INS hydrostatic pressure (middle), and CD water reabsorption rate (bottom) as functions of DVR contact length. Because DVR luminal fluid is assumed to be dilute relative to CD, a stronger coupling between the INS and DVR results in more dilute INS fluid (see top) and, together with a higher INS hydraulic pressure (see middle), decreases water absorption from the CD (see bottom). ●, Base-case values. J_V, water flux.