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Effects of ATL luminal urea concentration on INS fluid composition and water absorption from CD. A high ATL urea permeability (80 × 10−5 cm/s) is assumed. As ATL urea concentration increases, interstitial fluid urea concentration and osmolality increase (see top), leading to increase in CD water reabsorption rate (see bottom). Middle, INS pressure. Positive CD JV denotes water secretion into CD.
