Figure 3.

Agonistic antibodies to CD40 cannot prevent viral reactivation in the absence of CD8 T cells. MHC Class II −/− mice were infected with MHV-68 and treated with anti-CD40 or an isotype control antibody as described in the legend to Fig. 1. A group of anti-CD40-treated mice was also depleted of CD8 T cells by treatment with mAb 2.43 commencing 18 days after infection. Lung virus titers were determined 50 days after infection. Data are expressed as log₁₀ pfu/0.1 g of lung tissue for individual mice and are derived from two separate experiments.