. Author manuscript; available in PMC: 2012 Jul 1.

Published in final edited form as: Clin Lung Cancer. 2011 Nov 3;13(2):81–89. doi: 10.1016/j.cllc.2011.08.002

Table 1.

Characteristics of 10 Individual Studies

Author	Year	Quality Score	Study Type	Modality	Positive Nodal Definition	Reference	Patients (No.)	Stage	N1^a NPV	N2^a NPV	Overall^a,^b NPV

Farrell et al²⁴	2000	12	Retro	PET & CT^c	Visual^d or size^e	M, T^f	65	I	0.97	1.0	0.97

Konishi et al²⁵	2003	14	Retro	PET & CT	Visual or size	T	41	I	0.95	0.98	0.93

Cerfolio et al²⁶	2005	15	Pro	PET/CT,^g CT^h	SUV (≥ 2.5) or size	M, T, EUS-FNA	140	I	NA	0.91	NA

Kim et al²⁷	2006	16	Pro	PET/CT, CT	Visual or SUV (≥ 3.5)	M, T	134	IA	NA	0.87	NA

Lee et al²⁸	2007	10	Retro	PET & CT	SUV or size	M, T	224	I	NA	0.93	NA
							155	IA	NA	0.94	NA
							69	IB	NA	0.91	NA

Veeramachaneni et al²⁹	2008	11	Pro	PET & CT	PET-NAⁱ or size	M, T	108	IA	0.94	0.95	0.90

Herth et al³⁰	2008	15	Pro	PET & CT	SUV (≥ 2.5) or size	M, T, EBUS-TBNA	97	I	0.97	0.94^b	0.91

Maeda et al³¹	2009	10	Retro	PET/CT, CT	SUV or size	T	58	IA	0.85	0.95	0.79

Gómez-Caro et al³²	2010	16	Pro	PET/CT, CT	Visual or size	T	108	I	0.82	0.86	0.68
							47	IA	0.89	0.87	0.76
							61	IB	0.75	0.85	0.60

Park et al³³	2010	11	Retro	PET/CT, CT	Visual or size	M, T	147	IA	0.91	0.95	0.86

Abbreviations: EBUS-TBNA = endobronchial ultrasound-guided transbronchial needle aspiration; EUS-FNA = endoscopic ultrasound-guided fine-needle aspiration; M = mediastinoscopy; NA = not available; NPV = negative predictive value; Pro = prospective; Retro = retrospective; SUV = maximum standard uptake value.

N1, hilar nodal metastasis alone; N2, mediastinal nodal metastasis with or without N1 disease; overall, positive nodal disease at N1 or N2.

Includes both N2 and N3 metastases.

Visually reviewed PET and CT side by side.

Visually higher uptake than surrounding normal tissue.

Short axis of lymph nodes.

Thoracotomy with nodal dissection/sampling.

Integrated PET and CT.

Dedicated CT.

ⁱ

Positive PET finding without description of cutoff.