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. 2012 May 7;7(5):e36779. doi: 10.1371/journal.pone.0036779

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Link et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Chromosomes carrying both DRB1*15 and the protective class I haplotype do not differ in risk of MS from chromosomes not carrying either of them (reference). DRB1*15 carriage increase risk of MS significantly and carriage of the class I haplotype significantly decrease risk of MS. Counts are measured in chromosomes and only individuals with estimated haplotypes with a probability of more than 80% were included. “+” = Chromosomes positive for the protective haplotype or DRB1*15, “−” and “H−” = chromosomes negative for DRB1*15 or the protective haplotype. OR = odds ratio with 95% confidence interval, nominal p-value and Bonferroni corrected p-values derived from chi square test with doubly negative chromosomes as reference.