Table 2. Risk carried by each of the nominally significant allele groups in the logistic regression model for carriage coded DRB1*15 negative and positive strata.
DRB1*15 negative | |||||
Allele group | p-value (nominal) | p-value (FDR) | OR (95% C.I.) | Frequency Cases (%) | Frequency Controls (%) |
B*14 | 0.00040 | 0.0018 | 2.08 (1.39–3.13) | 4.0 | 2.2 |
A*02 | 0.00086 | 0.0026 | 0.72 (0.59–0.87) | 27.8 | 34.7 |
DRB1*07 | 0.0032 | 0.0058 | 0.66 (0.5–0.87) | 6.8 | 9.9 |
B*12 | 0.0045 | 0.0068 | 0.71 (0.56–0.9) | 9.3 | 14.2 |
A*10 | 0.012 | 0.012 | 1.52 (1.09–2.1) | 6.3 | 3.7 |
B*18 | 0.011 | 0.012 | 1.69 (1.13–2.54) | 4.0 | 2.2 |
Country of origin and gender were included in the models as covariates. DRB1*15 was coded as dose (0,1,2), all other allele groups were coded for carriage (0,1).