Table 4. Frequencies of estimated haplotypes, odds ratios and p-values from logistic regression with the 20 most common haplotypes.
Haplotype | ||||||||||||
No. | HLA-A | HLA-C | HLA-B | HLA-DRB1 | Cases | Controls | Frequency Cases (%) | Frequency Controls (%) | Frequency Total (%) | Nominal p-value | FDR corrected p-value | Odds Ratio (95% CI) |
1. | 1 | 7 | 8 | 3 | 207 | 240 | 7.0 | 8.6 | 7.7 | 0.022 | 0.033 | 0.78 (0.63–0.96) |
2. | 3 | 7 | 7 | 15 | 226 | 118 | 7.6 | 4.2 | 6.0 | 2.97×10−07 | 2.28×10−06 | 1.90 (1.49–2.44) |
3. | 2 | 7 | 7 | 15 | 179 | 59 | 6.0 | 2.1 | 4.1 | 1.18×10−12 | 2.72×10−11 | 3.14 (2.31–4.34) |
4. | 2 | 3 | 15 | 4 | 53 | 86 | 1.8 | 3.1 | 2.4 | 0.0066 | 0.015 | 0.60 (0.42–0.87) |
5. | 3 | 4 | 35 | 1 | 42 | 72 | 1.4 | 2.6 | 2.0 | 0.0030 | 0.0087 | 0.54 (0.36–0.81) |
6. | 2 | 5 | 12 | 4 | 25 | 81 | 0.8 | 2.9 | 1.8 | 1.39×10−07 | 1.60×10−06 | 0.28 (0.17–0.45) |
7. | 9 | 7 | 7 | 15 | 78 | 23 | 2.6 | 0.8 | 1.7 | 1.45×10−06 | 8.33×10−06 | 3.30 (2.06–5.47) |
8. | 2 | 3 | 40 | 6 | 38 | 56 | 1.3 | 2.0 | 1.6 | 0.068 | 0.097 | 0.67 (0.43–1.03) |
9. | 10 | 12 | 18 | 15 | 44 | 22 | 1.5 | 0.8 | 1.1 | 0.011 | 0.021 | 2.00 (1.19–3.48) |
10. | 3 | 3 | 15 | 4 | 33 | 15 | 1.1 | 0.5 | 0.8 | 0.0078 | 0.016 | 2.35 (1.27–4.52) |
11. | 1 | 6 | 37 | 15 | 37 | 10 | 1.2 | 0.4 | 0.8 | 0.00021 | 0.00095 | 3.87 (1.97–8.35) |
12. | 2 | 5 | 12 | 15 | 24 | 23 | 0.8 | 0.8 | 0.8 | 0.80 | 0.82 | 0.92 (0.51–1.69) |
13. | 1 | 7 | 7 | 15 | 30 | 15 | 1.0 | 0.5 | 0.8 | 0.020 | 0.032 | 2.15 (1.15–4.19) |
14. | 11 | 4 | 35 | 1 | 22 | 21 | 0.7 | 0.8 | 0.7 | 0.59 | 0.68 | 1.19 (0.63–2.23) |
15. | 19 | 16 | 12 | 7 | 21 | 22 | 0.7 | 0.8 | 0.7 | 0.82 | 0.82 | 0.93 (0.49–1.74) |
16. | 19 | 3 | 40 | 4 | 12 | 31 | 0.4 | 1.1 | 0.7 | 0.0063 | 0.015 | 0.38 (0.18–0.74) |
17. | 2 | 7 | 8 | 3 | 16 | 26 | 0.5 | 0.9 | 0.7 | 0.076 | 0.10 | 0.56 (0.29–1.05) |
18. | 2 | 3 | 40 | 4 | 17 | 24 | 0.6 | 0.9 | 0.7 | 0.20 | 0.26 | 0.65 (0.34–1.25) |
19. | 2 | 3 | 15 | 6 | 16 | 24 | 0.5 | 0.9 | 0.7 | 0.23 | 0.28 | 0.67 (0.34–1.27) |
20. | 3 | 7 | 7 | 4 | 16 | 18 | 0.5 | 0.6 | 0.6 | 0.66 | 0.72 | 0.85 (0.42–1.71) |