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. 2012 May 7;7(5):e36754. doi: 10.1371/journal.pone.0036754

Figure 4. Attenuation of cardiac hypertrophy in AAV9-KLF15 mice.

Figure 4

a) Body weight is not different in sham and AngII treated animals. b) AngII induces hypertrophy in GFP expressing mice, as measured by correcting the left ventricular weight (LVw) for body weight (Bw). This effect is blunted in mice with cardiac specific overexpression of KLF15. c and d) The hypertrophic response was also measured by analysis of individual cardiomyocyte size. Mice overexpressing KLF15 showed a blunted hypertrophic response to AngII. AU: arbitrary units. Scale bar in d represents 50 µm e) Quantitative real-time PCR on left ventricular tissue showed an increased expression of the hypertrophic markers ANF and alpha skeletal actin (aSKA) in GFP mice treated with angiotensin. In mice that overexpress KLF15 we found a reduction in expression of these genes, but this is not significant. * p<0.05 compared to GFP control. # p<0.05 compared to GFP ANGII.