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. 2012 May 7;7(5):e35992. doi: 10.1371/journal.pone.0035992

Figure 3. Initial inflammatory responses to Salmonella are independent of specific virulence factors.

Figure 3

A) PMN infiltration 3 h post administration of various live Salmonella mutants in BALB/c mice. Data for formalin (FA) killed wildtype Salmonella are also shown. Significance of differences to baseline levels (open circles) was determined using t-test on log-transformed data (***, P<0.001; **, P<0.01; *, P<0.05). B) PMN infiltration (filled circles) in Peyer’s patches of C57BL/6 mice at various time intervals post infection with avirulent Salmonella aroA asd. Means and standard deviations are shown for groups of three to four mice. No colony-forming units were recovered from day one post infection consistent with rapid in vivo lysis of this cell wall-deficient strain. Similar data were obtained in an independent experiment. C) Colonization levels of attenuated Salmonella aroA (open triangles) and PMN infiltration (filled circles) in Peyer’s patches at various time intervals post infection in BALB/c mice. Means and standard errors are shown for groups of six to eight mice from two independent experiments.