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. 2012 May 7;7(5):e36069. doi: 10.1371/journal.pone.0036069

Figure 3. Dose-response curves of GFP induction in transgenic cyp19a1b-GFP embryos by various ligands (17α-ethinylestradiol is used as a reference).

Figure 3

(a) Natural estrogens and pharmaceutical compounds: EE2: 17α-ethinylestradiol; E2: 17β-estradiol; E1: estrone; E3: estriol; DES: diethylstilbestrol; HEX: hexestrol; GEN: genistein; α-ZEA: α-zearalenol; α-ZEE: α-zearalanol; β-ZEE: β-zearalanol. The hexestrol curve in red is hardly visible because it is very similar to that of DES. (b) Industrial chemicals: BPA: bisphenol A; 4-t-PP: 4-t-pentylphenol; 4-t-OP, 4-t octylphenol; NPmix: mixture of nonylphenol. (c) Insecticides: o,p’DDT: 1,1,1-Trichloro-2-(2-chlorophenyl)-2-(4-chlorophenyl)ethane; MXC: methoxychlor; HPTE 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane. (d) Androgens: Testo: testosterone; DHT: dihydotestosterone; 17α-MT: 17α-methyltestosterone; 17β-Trenb: 17β-trenbolone; Noreth.: 17α-Ethynyl-19-nortestosterone (norethindrone); D(-)N: 13β-Ethyl-17α-ethynyl-17β-hydroxygon-4-en-3-one (levonogestrel), ICI (ICI 182-780); R1881 (metribolone): androgen receptor agonist.