Table 2.
Network analysis representing functional association of 39 genes with altered expression at prenatal lead levels > 10 μg/dL.
Gene Ontology biological process | Q-value | Count [annotated (overall)] | ||
---|---|---|---|---|
Neuron development | ||||
Negative regulation of axonogenesis | 0.00080 | 4 (13) | ||
Negative regulation of cell projection organization | 0.00328 | 4 (21) | ||
Negative regulation of neurogenesis | 0.00634 | 4 (27) | ||
Nerve growth factor receptor signaling pathway | 0.00990 | 7 (215) | ||
Regulation of axonogenesis | 0.00990 | 4 (34) | ||
Regulation of neuron projection development | 0.08320 | 4 (63) | ||
Cell development | ||||
Negative regulation of cell development | 0.01040 | 4 (36) | ||
Negative regulation of cell differentiation | 0.10500 | 5 (148) | ||
Immune response | ||||
Response to abiotic stimulus | 0.08320 | 6 (218) | ||
T-cell receptor signaling pathway | 0.08490 | 4 (67) | ||
Data are Gene Ontology categories (http://www.geneontology.org/) and Q-values (minimum FDR at which the test is considered significant) from an FDR-corrected hypergeometric test for enrichment. Q-Values were estimated using the Benjamini–Hochberg procedure. Counts reflect genes with this annotation in the query set (39 genes of interest identified by differential monotonous change of expression in response to lead exposure) compared with the overall number of genes in the GeneMANIA background set with this annotation and at least one interaction (numbers in parentheses). |