Fig. 2.

Pedigrees of three recently identified index patients with mutation p.S13F. Square symbols indicate men, circles women. Black solid symbols: clinical diagnosis DRM; half-closed symbols (vertical bar) indicate a possible diagnosis of DRM, dots indicate mutation carriers. Diagonal lines through symbols indicate the patient has died, arrow indicates index patient in each family. Abbreviations: (c)AVB = (complete) atrioventricular block, D = death, DCM = dilated cardiomyopathy, E: S13F = carrier of p.S13F mutation, E: - = not a carrier of p.S13F mutation, ICD = implantable cardioverter defibrillator, LBTB = left bundle branch block, LGMD = limb-girdle muscular dystrophy, LV = left ventricle, PM = pacemaker, PVC premature ventricular contraction, y = years