4.

Do QTLs with effects on hearing at 22 months affect mice with and without noise exposure? Each panel shows a locus detected by a significant effect on ABR tested at 22 months of age (see Table 2), either in noise-exposed mice, mice not exposed to noise, or in both groups pooled. Each symbol shows the effect size, in dB, at 22 months of age, at the indicated frequency, either in the No Noise group or in the Noise Rx group. The allele shown (MOLF or 129) indicates the allele associated with higher ABR values at the frequency that achieved experiment-wise significance (see Table 2). The error bars show the 95% confidence interval for the estimated effect. Entries that do not cross the horizontal line at zero are significant, at two-tailed p < 0.05, without correction for multiple comparisons. Evaluation of the QTL at 12•17 (not shown) closely resembles that shown for 12•40.