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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Neurobiol Aging. 2012 Feb 2;33(8):1842.e15–1842.e29. doi: 10.1016/j.neurobiolaging.2011.12.034

Table 3.

QTL with effects on the number of missing outer hair cells (OHC) tested at 22 months of age

Test Groupa Region Positionb Pct Expc Cells Missing in: p(e)
Combined Base 10*3 6.7 129 0.000
 Noise Rx Base 10*3 14.5 129 0.005
Combined Base 10*44 6.2 129 0.000
Combined Apex 11*72 6.4 MOLF 0.000
Combined Apex 12*117 6.7 129 0.000
Combined Apex 17*42 5.6 129 0.005
Combined Apex 19*12 5.6 129 0.002
 Noise Rx Apex 19*12 9.2 129 0.012
Combined Apex 19*17 4.8 129 0.013
 Noise Rx Apex 19*17 10.8 129 0.004
a

Test group: Noise-Rx - mice exposed to 2 hr noise at 20 months of age. Combined: both groups pooled, with noise exposure treated as a covariate in estimation of QTL effect.

b

Position is given as [chromosome] • [position in megabase pairs]

c

“Pct Exp” is the percentage of phenotypic variance attributable to the indicated allele.

dp(e) is experiment-wise p-value Numbers of mice: 122 – 164 for Noise-Rx; 253 – 322 for Combined groups.

Colored bands indicate the most parsimonious genetic model for OHC pathology at 22 months, based on the distinctions of chromosome and grandparental allele. Separate rows are included for Noise-Rx mice only when p(e) < 0.05 for the analysis in that subset of mice.