TABLE 1.
Summary of Cre lines described in the review
| Conditional allele | Type | Expression pattern | Level of expression | Original citation | Source |
|---|---|---|---|---|---|
| Atoh1-Cre | Knock-in | E13.5: vestibular sensory regions; E14.5: basal turn of the cochlea; P0: HCs and SCs in cochlea and vestibular organs | Cochlear and vestibular HCs (90 %), cochlear SCs (60 %), utricle SCs (6 %), saccule SCs (15 %), cristae SCs (42 %) | Yang et al. (2010a) | Not commercially available |
| Atoh1-Cre | Transgenic | E11: otocyst; E18.5: HCs and SCs in cochlea and vestibular organs, spiral and vestibular ganglion neurons | Cre expression not quantified | Matei et al. (2005) | Jax stock #11104 |
| CAG-Cre | Transgenic | Ubiquitous expression | Cre expression not quantified | Sakai and Miyazaki (1997) | Not commercially available |
| Col1A1-Cre | Transgenic | Not characterized with a reporter line | Liu et al. (2004) | MMRRC stock #15398-UCD | |
| Col2A1-Cre | Transgenic | E10.5: non-sensory regions of the otocyst and mesenchymal cells | Cre expression not quantified | Ovchinnikov et al. (2000) | Jax stock #3554 |
| Fgf16-Cre | Knock-in | E10.5: otic vesicle; P1: semicircular canal cristae, stria vascularis, cochlear spiral prominence epithelium | Cre expression not quantified | Hatch et al. (2009) | Not commercially available |
| Foxg1-Cre | Knock-in | E8.5: otic placode; E13.5: cochlea, vestibular organs, spiral and vestibular ganglia | Cre expression not quantified | Hebert and McConnell (2000) | Jax stock #4337 |
| hGFAP-Cre | Transgenic | E13.5: utricle, cristae, non-sensory cells around vestibular organs, postnatal cochlear SCs | Cre expression not quantified | Zhuo et al. (2001) | Jax stock #4600 |
| Gfi1-Cre | Knock-in | E13.5: vestibular HCs; E15.5: cochlear HCs in basal turn; E18.5: cochlear and vestibular HCs | Cochlear HCs (93 %), HCs in utricle, saccule, and cristae (90 %) | Yang et al. (2010b) | Not commercially available |
| Hoxb2-r4-Cre | Transgenic | E8.5: otic placode; P0: cochlea, vestibular organs, spiral and vestibular ganglia | Cre expression not quantified | Szeto et al. (2009) | Not commercially available |
| Otog-Cre | Transgenic | Not characterized with a reporter line | Cohen-Salmon et al. (2002) | Not commercially available | |
| Pax2-Cre | BAC transgenic | E8.5: otic placode; P0: cochlea, vestibular organs, spiral and vestibular ganglia | Cre expression not quantified | Ohyama and Groves (2004) | MMRRC stock #10569-UNC |
| Pax3-Cre | Knock-in | E9: otic vesicle and developing spiral and vestibular ganglion; E11.5 to E17.5: cochlea, utricle and saccule | Cre expression not quantified | Engleka et al. (2005) | Jax stock #5549 |
| Pax8-Cre | Knock-in | E8.5: otic placode; E16.5: epithelial components of the inner ear and spiral and vestibular ganglia | Cre expression not quantified | Bouchard et al. (2002) | EMMA stock #EM:00141 |
| Pou3f4-Cre | Transgenic | E14.5: otic mesenchyme, adult: temporal bone, spiral ligament, spiral limbus, tympanic border cells, Reissner’s membrane, mesenchymal cells, non-sensory cells in utricle | Cre expression not quantified | Ahn et al. (2009) | Not commercially available |
| Pou4f3-Cre | Transgenic | E12.5: utricle sensory epithelium; E13.5: zone of non-proliferating cells in cochlea; P6: cochlear HCs and SCs, vestibular HCs and stroma | Cre expression not quantified | Sage et al. (2006) | Not commercially available |
| Prestin-Cre | BAC transgenic | P6: cochlear and vestibular HCs, spiral ganglia region | Cre expression not quantified | Tian et al. (2004) | Not commercially available |
| Prestin-Cre | Transgenic | P14: cochlear inner HCs, vestibular HCs, spiral ganglia region; P50: last row of cochlear outer HCs | Cre expression not quantified | Li et al. (2004) | Not commercially available |
| Prox1-eGFP/Cre | Knock-in | P23: cochlear HCs, pillar cells, Deiters’ cells, GER and LER | Outer HCs (30 %), inner HCs (4 %), pillar cells and Deiters’ cells (almost 100 %) | Liu et al. (2012) | Not commercially available |
| SHH-EGFP/Cre | Knock-in | P0: spiral ganglion neurons, peripheral nerve fibers surrounding HCs and SCs | Spiral ganglion neurons (100 %) | Harfe et al. (2004) | Jax stock #5622 |
| Sox2-Cre | Transgenic | Ubiquitous expression | Cre expression not quantified | Hayashi et al. (2002) | Jax stock #4783 |
| Wnt1-Cre | Transgenic | E9: otic vesicle, developing spiral and vestibular ganglion; E11.5 to E17.5: cochlea, utricle and saccule | Cre expression not quantified | Danielian et al. (1998) | Jax stock #3829 |