TABLE 2.
Summary of CreER lines described in the review
| Conditional allele | Type | Tamoxifen induction | Expression pattern | Original citation | Source |
|---|---|---|---|---|---|
| Atoh1-CreERTM | Transgenic | E16 only | Cochlear HCs (not quantified) | Chow et al. (2006) | MMRRC stock #29581-UNC |
| P0 only | Cochlear inner HCs (40 %), outer HCs (50 %), utricle and saccule HCs (40 %), cristae HCs (10 %) | ||||
| P0 and P1 | Cochlear inner HCs (80 %), outer HCs (90 %), utricle and saccule HCs (60 %), cristae HCs (15 %) | ||||
| P0, P1, and P2 | Cochlear inner HCs (80 %), outer HCs (90 %), utricle and saccule HCs (60 %), cristae HCs (20 %) | ||||
| Atoh1-CreERT2 | Transgenic | E12.75 | Cochlear inner HCs (40 %), outer HCs (44 %) | Machold and Fishell (2005) | Jax stock #7684 |
| E12.75 and E13.75 | Cochlear inner HCs (90 %), outer HCs (97 %) | ||||
| P0 and P1 | Cochlear HCs (10–20 % depending on turn), utricle HCs (not quantified) | ||||
| CAG-CreERTM | Transgenic | Varies | Ubiquitous expression | Hayashi and McMahon (2002) | Jax stock #4453 |
| Fgfr3-iCreERT2 | PAC transgenic | P0 and P1 | Pillar and Deiters’ cells (100 %), cochlear outer HCs (25–75 % depending on turn), Hensen or Claudius cells (not quantified), spiral lamina | Rivers et al. (2008) | Not commercially available |
| P2 and P3 | Pillar and Deiters’ cells (100 %), cochlear outer HCs (>30 % depending on turn), Hensen or Claudius cells (not quantified), spiral lamina | ||||
| P6 and P7 | Pillar and Deiters’ cells (100 %), cochlear outer HCs (>20 % depending on turn), Hensen or Claudius cells (not quantified), spiral lamina | ||||
| P12 and P13 or P30 | Pillar and Deiters’ cells (100 %), Hensen or Claudius cells (not quantified), spiral lamina | ||||
| Ngn1-CreERT2 | BAC transgenic | E8.5 to E13.5 | HCs, SCs and non-sensory epithelium of vestibular organs, spiral and vestibular ganglia, GER (no quantifications were done) | Raft et al. (2007) | Jax stock #8529 |
| E8.5 only | Vestibular ganglion neurons (not quantified) | ||||
| E12.5 only | Spiral ganglion neurons (not quantified) | ||||
| Plp-CreERT2 | Transgenic | P0–P7, P3–P9, or P10-P16 | Inner phalangeal cells, Schwann cells in the spiral lamina, vestibular SCs, vestibular Schwann cells and satellite cells (no quantifications were done) | Doerflinger et al., (2003) | Jax stock #5975 |
| P0 and P1 | Inner phalangeal cells (50–80 % depending on turn), pillar and Deiters’ cells (5–10 %), utricle HCs and SCs (not quantified) | ||||
| Prestin-CreERT2 | Knock-in | P0, P1, and P2 | Cochlear outer HCs (15–60 % depending on turn) | Fang et al. (2012) | Not commercially available |
| P2 and older | Cochlear outer HCs (100 %) | ||||
| Prox1-CreERT2 | Knock-in | E16 | Deiters’ cells (72 %), outer pillar cells (18 %), inner pillar cells (3 %), cochlear outer HCs (7 %) | Srinivasan et al. (2007) | Not commercially available |
| P0 and P1 | Pillar cells (5 %), Deiters’ cells (5–10 %) | ||||
| ROSA26-CreER | Knock-in | Varies | Ubiquitous expression | Vooijs et al. (2001) | Not commercially available |
| ROSA26-CreER | Knock-in | Varies | Ubiquitous expression | Badea et al. (2003) | Jax stock #4847 |