Atoh1-CreERTM
|
Transgenic |
E16 only |
Cochlear HCs (not quantified) |
Chow et al. (2006) |
MMRRC stock #29581-UNC |
P0 only |
Cochlear inner HCs (40 %), outer HCs (50 %), utricle and saccule HCs (40 %), cristae HCs (10 %) |
P0 and P1 |
Cochlear inner HCs (80 %), outer HCs (90 %), utricle and saccule HCs (60 %), cristae HCs (15 %) |
P0, P1, and P2 |
Cochlear inner HCs (80 %), outer HCs (90 %), utricle and saccule HCs (60 %), cristae HCs (20 %) |
Atoh1-CreERT2
|
Transgenic |
E12.75 |
Cochlear inner HCs (40 %), outer HCs (44 %) |
Machold and Fishell (2005) |
Jax stock #7684 |
E12.75 and E13.75 |
Cochlear inner HCs (90 %), outer HCs (97 %) |
P0 and P1 |
Cochlear HCs (10–20 % depending on turn), utricle HCs (not quantified) |
CAG-CreERTM
|
Transgenic |
Varies |
Ubiquitous expression |
Hayashi and McMahon (2002) |
Jax stock #4453 |
Fgfr3-iCreERT2
|
PAC transgenic |
P0 and P1 |
Pillar and Deiters’ cells (100 %), cochlear outer HCs (25–75 % depending on turn), Hensen or Claudius cells (not quantified), spiral lamina |
Rivers et al. (2008) |
Not commercially available |
P2 and P3 |
Pillar and Deiters’ cells (100 %), cochlear outer HCs (>30 % depending on turn), Hensen or Claudius cells (not quantified), spiral lamina |
P6 and P7 |
Pillar and Deiters’ cells (100 %), cochlear outer HCs (>20 % depending on turn), Hensen or Claudius cells (not quantified), spiral lamina |
P12 and P13 or P30 |
Pillar and Deiters’ cells (100 %), Hensen or Claudius cells (not quantified), spiral lamina |
Ngn1-CreERT2
|
BAC transgenic |
E8.5 to E13.5 |
HCs, SCs and non-sensory epithelium of vestibular organs, spiral and vestibular ganglia, GER (no quantifications were done) |
Raft et al. (2007) |
Jax stock #8529 |
E8.5 only |
Vestibular ganglion neurons (not quantified) |
E12.5 only |
Spiral ganglion neurons (not quantified) |
Plp-CreERT2
|
Transgenic |
P0–P7, P3–P9, or P10-P16 |
Inner phalangeal cells, Schwann cells in the spiral lamina, vestibular SCs, vestibular Schwann cells and satellite cells (no quantifications were done) |
Doerflinger et al., (2003) |
Jax stock #5975 |
P0 and P1 |
Inner phalangeal cells (50–80 % depending on turn), pillar and Deiters’ cells (5–10 %), utricle HCs and SCs (not quantified) |
Prestin-CreERT2
|
Knock-in |
P0, P1, and P2 |
Cochlear outer HCs (15–60 % depending on turn) |
Fang et al. (2012) |
Not commercially available |
P2 and older |
Cochlear outer HCs (100 %) |
Prox1-CreERT2
|
Knock-in |
E16 |
Deiters’ cells (72 %), outer pillar cells (18 %), inner pillar cells (3 %), cochlear outer HCs (7 %) |
Srinivasan et al. (2007) |
Not commercially available |
P0 and P1 |
Pillar cells (5 %), Deiters’ cells (5–10 %) |
ROSA26-CreER |
Knock-in |
Varies |
Ubiquitous expression |
Vooijs et al. (2001) |
Not commercially available |
ROSA26-CreER |
Knock-in |
Varies |
Ubiquitous expression |
Badea et al. (2003) |
Jax stock #4847 |