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Direct activation of the distal TCR signaling cascade results in translocation of NF-κB into the nucleus of nasal polyp-derived T cells. Following activation with PMA and ionomycin, the percentage of CD3+ T cells translocating NF-κB is not significantly different in nasal polyp tissue (95.6%, n = 5) versus normal donor PBL (97.2%, n = 8), patient PBL (96.7%, n = 3), or tonsillar tissue (95.5%, n = 2).
