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. 2001 May 22;98(11):6336–6341. doi: 10.1073/pnas.101133498

Figure 3.

Figure 3

Effect of HN polypeptides on neuronal cell death by FAD genes. (A) F11 cells were transfected with V642I-APP cDNA and were treated with various concentrations of sHN, sHNG, sHNA, the dimer form of sHN through C8 (C8-C8), and sHN whose C-terminal KRRA was replaced with AAAA (KRRA to AAAA). Seventy-two hours after transfection, cell mortality was measured by Trypan blue exclusion assay. (B) F11 cells were transfected with M146L-PS1 or N141I-PS2 cDNA, and were treated with various concentrations of sHN, sHNG (S14G), or sHNA (C8A). Seventy-two hours after transfection, cell mortality was similarly measured.