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Schematic view of the role of apoptotic keratinocytes in vitiligo. Keratinocytes produce and release numerous synergistic mitogens in culture, such as stem cell factor (SCF), endothelins (ETs), basic fibroblast growth factor (bFGF). In contrast, apoptotic keratinocytes provide these growth factors less than that of normal keratinocytes, inducing passive melanocyte death due to the loss of survival stimuli.
