Table 1.
Source | Definition | Drawbacks |
---|---|---|
Donor/recipient | ||
Autologous | Same individual | Not always available (genetic diseases, age) |
Allogenic | Same species | Immunological issues |
Xenogenic | Different species | Ethical issues and rejection |
Syngenic or isogenic | Genetically identical individuals (clones, inbred) | Most appropriate for research with animal model |
| ||
Origin/differentiation | ||
| ||
Primary | Tissue or organ/specialized | Large expansion needed |
Secondary | Cell bank | Cryopreservation/immunological issues |
Embryonic stem cells (iPSCs) | Undifferentiated | Ethical issues/purification/teratoma |
Adult stem cells | Commited | Selection of type/source |