Table 3.
ICG cytotoxicity studies.
| Cell | Type | Ref. | Comment |
|---|---|---|---|
| ARPE19 | In vitro | [54] | ICG 1 mg/mL; not toxic |
| RPE | In vitro | [55] | IfCG; no damage |
| Glial cell | Ditto | Ditto | ditto; some damage |
| RPE | Rabbit | [56] | ICG; no damage |
| RPE | Ditto | Ditto | IfCG; no damage |
| RPE | Gene expr. | [57] | Cell cycle arrest and apoptosis |
| Ditto | Ditto | Ditto | 0.25 mg/mL recommended |
| Müller | In vitro | [41] | Fluorescent lamp illumination: |
| Ditto | Ditto | Ditto | induces cytotoxicity |
| Intravenous | Rat | [58] | IRDye 800CW; no toxicity obs. |
| Intradermal | Ditto | Ditto | Ditto; ditto |
| Spin. root ax. | Rat | [59] | Neurotoxicity observed |
| RPE | Human cult. | [60] | Growth inhibition and damage |
| RPE | Human cult. | [61] | ICG interactions with RPE |