Table 3.

Parameter values for SERCA (uptake), NCX, and background leak fluxes.

Symbol	Definition	Value
vup	Maximum pump rate of SERCA	0.32 μM ms−1
kup	Half-maximal activation constant for SERCA	1.0 μM
v2	Adjustable pump rate constant of NCX	0.4 μM ms−1
η	NCX voltage sensitivity constant	0.35
F	Faraday’s constant	96.5 C mmol−1
R	Gas constant	8.314 J M−1 K − 1
T	Temperature	310 K
[Ca]0	External [Ca]	1.80 mM
[Na]0	External [Na]	136 mM
$K_{mC{a}_{act}}$	Allosteric Ca inactivation constant	0.11 μM
$K_{mC{a}_o}$	External Ca sensitivity constant	1.30 mM
$K_{mN{a}_o}$	External Na sensitivity constant	87.5 mM
$K_{mC{a}_i}$	Internal Ca sensitivity constant	3.59 μM
$K_{mN{a}_i}$	Internal Na sensitivity constant	12.3 mM
ksat	NCX saturation constant	0.27
gbg	Rate of background membrane leak	0.0003·10−5 μM ms−1
gSRleak	Rate of SR leak	4.0·10−6 ms−1