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Blocking MMP activity inhibits LPA-induced junction loss. (a) OVCA429 cells were treated with LPA (30 μM) for 24 hours in the presence and absence of the broad-spectrum MMP inhibitor GM6001 (25 μM) as indicated and processed for E-cadherin immunofluorescence (green). (b) E-cadherin positive cells were quantified by scoring the number of cells with two remaining borders in a minimum of 12 fields per treatment. (*P < .0005 relative to control; + P = .007 relative to LPA).
