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. 2001 May 22;98(11):6348–6353. doi: 10.1073/pnas.101132598

Figure 2.

Figure 2

Localization of the 7p15 breakpoint to the centromeric end of BAC b459N13. (a) Map of the BAC and PAC clones in the centromeric region of YAC y908B12. STSs are shown at the top of the map at relative positions based on DNA sequence available for the region. (b) Position of Southern blot hybridization probes within DNA near the centromeric end of BAC b459N13. The approximate positions of chromosome 7p15 breakpoints in cases BWH-42 and -665, as determined in the Southern blots in c, are illustrated with upward arrows near the telomeric end of the region shown. (c) Southern blot analyses of DNA derived from the tumors in cases BWH-42 and -665. Normal DNA was extracted from fibroblasts of the patient in case BWH-42. The probes used for each blot are indicated above the autoradiograms; the restriction enzymes used are shown below. Arrowheads indicate the positions of rearranged restriction fragments; dashes the positions of the germline restriction fragments.