Figure 5.

Nucleotide and amino acid sequences of the chromosome 7 gene (JAZF1) and chromosome 17 gene (JJAZ1) joined in the t(7;17)(p15;q21). (a) The conceptually translated sequence of the largest ORF is shown below the sequence of the sense strand of the JAZF1 cDNA. The shaded boxes indicate the amino acids that code for C₂H₂ zinc finger domains. The breakpoint in the four cases of low-grade ESS analyzed by Northern blot and RT-PCR divided the coding sequence at the position of the vertical line (after nucleotide 435). (b) The sequence of JJAZ1 displayed as in a. The double underline indicates the amino acids that code a possible bipartite nuclear localization signal. The breakpoint in the four cases of low-grade ESS divided the coding sequence at the position of the vertical line (before nucleotide 469).