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Relative neurovirulence of the parental and miRNA target TBEV/DEN4 viruses in suckling mice
| Virus | i.c. LD50 (PFU) | Fold reductiona | ASTb (no. of days) |
|---|---|---|---|
| TBEV/DEN4 | 0.8 | 7.6 | |
| let-7cT | >100 | >125 | >21 |
| mir-9T | 5 | 6 | 14.5 |
| mir-124aT | 53 | 66 | 13 |
| mir-128aT | 1 | 9.7 | |
| mir-218T | <1 | 8.8 |
Fold reduction in neurovirulence for each miRNA target virus compared to the neurovirulence of the TBEV/DEN4 parent.
Average survival times (AST) of moribund mice following inoculation with 10 PFU of virus.
