Fig 1.

Altered expression of shelterin components in HIV-1-specific CD8 T cells from progressors. Box-and-whisker plots show the mRNA expression intensities (the minimum, the maximum, and the 25th, 50th, and 75th percentiles) of the indicated gene products in sorted HIV-1-specific CD8 T cells or autologous CMV/EBV-specific CD8 T cells or bulk CD8 from HIV-1 progressors or controllers. Gene expression was normalized to the housekeeping β-actin gene. Significance was tested using one-way analysis of variance (ANOVA), followed by post hoc analysis using the Tukey test for multiple comparisons (*, P < 0.05; **, P < 0.01).